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Table 3 Multi-trait colocalization analysis highlighted key role of metabolites and hormones (pp > 0 0.7)

From: Dissecting the genetic determinants and biological associations between body mass index and female reproductive disorders based on genome-wide association study

Trait pairs

Panel

Trait

loci_SNP

PP

RP

Post_exp_snp

BMI & GDM

Hormone

Insulin

rs13083375

0.932

0.994

0.403

BMI & EC

Hormone

Insulin

rs12602912

0.906

0.938

0.971

BMI & GDM

Glycolysis

Glucose

rs7713317

0.892

1.000

0.257

BMI & GDM

Amino acids

Glycine

rs1801282

0.889

0.994

0.399

BMI & GDM

Amino acids

Glutamine

rs1801282

0.869

0.961

0.329

BMI & GDM

Size & Apo-LP

Average diameter for VLDL particles

rs1801282

0.841

0.993

0.336

BMI & GDM

Size & Apo-LP

Average diameter for LDL particles

rs1801282

0.839

0.973

0.243

BMI & EC

Cholesterol

Cholesterol in large VLDL

rs12602912

0.831

0.991

0.665

BMI & EC

Triglycerides

Triglycerides in very small VLDL

rs12602912

0.830

0.991

0.677

BMI & EC

Free cholesterol

Free cholesterol in large VLDL

rs12602912

0.829

0.991

0.666

BMI & EC

Triglycerides

Triglycerides in large LDL

rs12602912

0.828

0.990

0.669

BMI & EC

Phospholipids

Phospholipids in large VLDL

rs12602912

0.828

0.990

0.673

BMI & EC

Triglycerides

Triglycerides in LDL

rs12602912

0.828

0.991

0.671

BMI & EC

Cholesterol

Cholesterol in very large VLDL

rs12602912

0.827

0.990

0.652

BMI & EC

Triglycerides

Triglycerides in medium LDL

rs12602912

0.827

0.990

0.673

BMI & EC

Triglycerides

Triglycerides in IDL

rs12602912

0.827

0.991

0.666

BMI & EC

Triglycerides

Triglycerides in small HDL

rs12602912

0.826

0.990

0.686

BMI & EC

Triglycerides

Triglycerides in medium VLDL

rs12602912

0.826

0.990

0.684

BMI & EC

Lipoprotein particles

Concentration of small VLDL particles

rs12602912

0.826

0.991

0.668

BMI & EC

Total lipids

Total lipids in large VLDL

rs12602912

0.825

0.990

0.673

BMI & EC

Lipoprotein particles

Concentration of large VLDL particles

rs12602912

0.825

0.990

0.669

BMI & EC

Total lipids

Total lipids in VLDL

rs12602912

0.824

0.990

0.657

BMI & EC

Triglycerides

Triglycerides in small VLDL

rs12602912

0.824

0.990

0.682

BMI & GDM

Triglycerides

Triglycerides in very large VLDL

rs1801282

0.823

0.983

0.372

BMI & EC

Free cholesterol

Free cholesterol in very large VLDL

rs12602912

0.823

0.990

0.648

BMI & EC

Phospholipids

Phospholipids in very large VLDL

rs12602912

0.822

0.990

0.650

BMI & GDM

Triglycerides

Triglycerides in large VLDL

rs1801282

0.819

0.988

0.377

BMI & EC

Triglycerides

Triglycerides in large VLDL

rs12602912

0.818

0.990

0.672

BMI & EC

Fatty Acids

Monounsaturated fatty acids

rs12602912

0.818

0.990

0.654

BMI & EC

Triglycerides

Triglycerides in HDL

rs12602912

0.818

0.987

0.671

BMI & EC

Lipoprotein particles

Concentration of very large VLDL particles

rs12602912

0.817

0.990

0.654

BMI & EC

Total lipids

Total lipids in very large VLDL

rs12602912

0.817

0.990

0.654

BMI & EC

Triglycerides

Triglycerides in small LDL

rs12602912

0.816

0.990

0.655

BMI & EC

Compounds

Total triglycerides

rs12602912

0.815

0.990

0.662

BMI & GDM

Triglycerides

Triglycerides in chylomicrons and extremely large VLDL

rs1899951

0.815

0.991

0.287

BMI & GDM

Lipoprotein particles

Concentration of chylomicrons and extremely large VLDL particles

rs1801282

0.813

0.977

0.333

BMI & EC

Triglycerides

Triglycerides in medium HDL

rs12602912

0.813

0.983

0.670

BMI & EC

Triglycerides

Triglycerides in VLDL

rs12602912

0.812

0.990

0.657

BMI & EC

Triglycerides

Triglycerides in very large VLDL

rs12602912

0.808

0.990

0.652

BMI & EC

Total lipids

Total lipids in small VLDL

rs12602912

0.807

0.991

0.664

BMI & EC

Esterified cholesterol

Cholesteryl esters in chylomicrons and extremely large VLDL

rs12602912

0.806

0.979

0.624

BMI & EC

Cholesterol

Cholesterol in chylomicrons and extremely large VLDL

rs12602912

0.806

0.983

0.617

BMI & EC

Fatty Acids

Total fatty acids

rs12602912

0.806

0.979

0.644

BMI & EC

Phospholipids

Phospholipids in VLDL

rs12602912

0.805

0.991

0.653

BMI & EC

Size & Apo-LP

Average diameter for HDL particles

rs12602912

0.800

0.976

0.609

BMI & EC

Free cholesterol

Free cholesterol in chylomicrons and extremely large VLDL

rs12602912

0.799

0.979

0.611

BMI & EC

Lipoprotein particles

Concentration of chylomicrons and extremely large VLDL particles

rs12602912

0.798

0.980

0.613

BMI & GDM

Phospholipids

Phospholipids in chylomicrons and extremely large VLDL

rs1801282

0.798

0.962

0.346

BMI & EC

Phospholipids

Phospholipids in chylomicrons and extremely large VLDL

rs12602912

0.791

0.967

0.617

BMI & EC

Fatty Acids

Saturated fatty acids

rs12602912

0.788

0.960

0.638

BMI & GDM

Total lipids

Total lipids in chylomicrons and extremely large VLDL

rs1801282

0.786

0.969

0.311

BMI & GDM

Triglycerides

Triglycerides in VLDL

rs1801282

0.784

0.958

0.381

BMI & EC

Esterified cholesterol

Cholesteryl esters in very large VLDL

rs12602912

0.781

0.990

0.647

BMI & EC

Total lipids

Total lipids in chylomicrons and extremely large VLDL

rs12602912

0.780

0.961

0.608

BMI & GDM

Compounds

Total concentration of lipoprotein particles

rs7550711

0.776

0.802

0.946

BMI & EC

Size & Apo-LP

Average diameter for VLDL particles

rs12602912

0.773

0.965

0.638

BMI & EC

Esterified cholesterol

Cholesteryl esters in large HDL

rs12602912

0.766

0.988

0.628

BMI & GDM

Lipoprotein particles

Concentration of HDL particles

rs7550711

0.766

0.793

0.949

BMI & EC

Cholesterol

Cholesterol in large HDL

rs12602912

0.762

0.986

0.626

BMI & GDM

Total lipids

Total lipids in very large VLDL

rs1801282

0.750

0.923

0.395

BMI & GDM

Lipoprotein particles

Concentration of very large VLDL particles

rs1801282

0.746

0.910

0.398

BMI & EC

Triglycerides

Triglycerides in chylomicrons and extremely large VLDL

rs12602912

0.745

0.922

0.607

BMI & GDM

Free cholesterol

Free cholesterol in chylomicrons and extremely large VLDL

rs1801282

0.741

0.905

0.359

BMI & GDM

Phospholipids

Phospholipids in very large HDL

rs891387

0.728

0.950

0.222

BMI & GDM

Compounds

Total triglycerides

rs1801282

0.727

0.893

0.400

BMI & GDM

Total lipids

Total lipids in very large HDL

rs891387

0.705

0.930

0.218

  1. Abbreviations: BMI, body mass index; PCOS, polycystic ovary syndrome; GDM, gestational diabetes mellitus; GH, gestational hypertension; PE, pre-eclampsia or eclampsia; EC, endometrial cancer; EnOC, endometrioid ovarian cancer; SAB, spontaneous abortion; PP, posterior probability; RP, regional probability; post_exp_snp, osterior_explained_by_snp
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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