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Table 1 Genetic correlation between BMI and female reproductive disorders

From: Dissecting the genetic determinants and biological associations between body mass index and female reproductive disorders based on genome-wide association study

Trait pairs

LDSC

HDL

rg (SE)

p value

rg (SE)

p value

BMI & GDM

0.448 (0.034)

5.876E-40*

0.554 (0.065)

8.580E-18*

BMI & GH

0.308 (0.030)

1.721E-24*

0.353 (0.035)

1.330E-23*

BMI & PE

0.328 (0.036)

1.566E-19*

0.377 (0.045)

4.030E-17*

BMI & ICP

0.003 (0.036)

9.350E-01

0.013 (0.034)

6.980E-01

BMI & FGR

-0.044 (0.054)

4.108E-01

-0.086 (0.069)

2.080E-01

BMI & SAB

0.209 (0.059)

4.380E-04*

0.427 (0.226)

5.870E-02

BMI & PTB

0.069 (0.038)

7.023E-02

0.089 (0.060)

1.380E-01

BMI & PPH

0.085 (0.056)

1.279E-01

0.083 (0.071)

2.440E-01

BMI & Infertility

0.027 (0.036)

4.539E-01

-0.007 (0.042)

8.690E-01

BMI & PCOS

0.323 (0.044)

1.756E-13*

0.669 (0.223)

2.760E-03

BMI & Menorrhagia

0.313 (0.044)

7.939E-13*

0.307 (0.045)

5.790E-12*

BMI & UPs

-0.076 (0.107)

4.753E-01

-Inf (NA)

NA

BMI & UF

0.023 (0.023)

3.001E-01

0.022 (0.023)

3.460E-01

BMI & Endometriosis

0.013 (0.025)

6.034E-01

-3e-04 (0.026)

9.900E-01

BMI & EC

0.488 (0.047)

3.632E-25*

0.411 (0.034)

2.520E-34*

BMI & EnOC

0.094 (0.073)

1.990E-01

0.134 (0.057)

1.840E-02

  1. Abbreviations: BMI, body mass index; PCOS, polycystic ovary syndrome; GDM, gestational diabetes mellitus; GH, gestational hypertension; PE, pre-eclampsia or eclampsia; EC, endometrial cancer; EnOC, endometrioid ovarian cancer; SAB, spontaneous abortion. * represents traits that pass the Bonferroni correction (p = 0.003 < 0.05/16)