Fig. 1

The overall design followed in the study is shown. BMI, body mass index; PCOS, polycystic ovary syndrome; GDM, gestational diabetes mellitus; GH, gestational hypertension; PE, pre-eclampsia or eclampsia; EC, endometrial cancer; EnOC, endometrioid ovarian cancer; SAB, spontaneous abortion; UFs, uterine fibroids, UPs, uterine polyps; ICP, intrahepatic cholestasis of pregnancy; FGR, poor fetal growth, PPH, postpartum hemorrhage, PTB, preterm labor and delivery; LDSC, linkage disequilibrium score regression; HDL, high-definition likelihood; PLACO, pleiotropic analysis under composite null hypothesis; MAGMA, multimarker analysis of GenoMic annotation; COLOC, colocolization analysis; SMR, summary-data based Mendelian randomization; HyPrColoc, Hypothesis Prioritization Colocalization. TSH, thyroid stimulating hormone; FT3, free triiodothyronine; FT4, free thyroxine; FSH, follicle-stimulating hormone; LH, luteinizing hormone; GH, growth hormone; and PRL, prolactin