Psychopharmacological interventions among people who use Assisted Reproductive Technology (ART) — a scoping review

Dawid, Storman; Paweł, Jemioło; Dominika, Adamska; Zuzanna, Sawiec

doi:10.1186/s12958-025-01400-4

Table 3 Map of psychiatric indications of medications

From: Psychopharmacological interventions among people who use Assisted Reproductive Technology (ART) — a scoping review

	Dosages/time	psychotic symptoms	anxiety	depression	insomnia	bipolar disorder	delirium
sedatives	NR/NR				Goisis, 2023 [18]
hipnotics	NR/NR				Goisis, 2023 [18]
zolpidem	NR/NR				McIntosh, 2010 [33]
lamotrigine	NR/NR					Freeman, 2016[15]
lithium	NR/NR					Siegel, 2022 [47] Freeman, 2016 [15]
valproic acid	NR/NR					Freeman, 2016 [15]
haloperidol	0,5 mg x 3/1 week						Mercan, 2005 [35]
atypical antipsychotics	NR/NR					Freeman, 2016 [15]
aripiprazole	25 mg d/NR	Rodrigues, 2014 [43]
olanzapine	NR/NR					Siegel, 2022 [47]
risperidone	NR/NR					Siegel, 2022 [47]
quetiapine	NR/NR					Siegel, 2022 [47]
clozapine	NR/NR					Siegel, 2022 [47]
antidepressants	NR/NR			Goisis, 2023 [18]
SSRI	NR/at least 1 month before and throughout the patient's IVF and continued 12 to 14 weeks'gestation		Hernandez-Nieto, 2017 [20]	Hernandez-Nieto, 2017 [20]		Siegel, 2022 [47]
sertraline	10–50 mg/at least 6 m		, 2016 [10]	Cesta, 2016 [10]
fluoxetine	20 mg (5 studies) to 60 mg (1 study)/from 26 d to several years ^a		Cesta, 2016 [10] Serafini, 2009 [46]	Cesta, 2016 [10] Keshavarz, 2020 [25] Keshavarz, 2021 [26] Ramezanzadeh, 2011[41] Applegarth, 2015 [3]
citalopram	NR/at least 6 m		Cesta, 2016 [10]	Cesta, 2016 [10]
paroxetine	NR/at least 6 m		Cesta, 2016 [10]	Cesta, 2016 [10]
fluvoxamine	NR/at least 6 m		Cesta, 2016 [10]	Cesta, 2016 [10]
escitalopram	5 mg d for a week, then 10 mg/at least 30 days before the first day of the menstrual cycle; 4 weeks during IVF cycle, total — 8 weeks or at least 6 m		Cesta, 2016 [10] Aisenberg Romano, 2019 [1]	Cesta, 2016 [10] Aisenberg Romano, 2019 [1]
venlafaxine	NR/at least 6 m		Cesta, 2016 [10]	Cesta, 2016 [10] McIntosh, 2010 [33]
clomipramine	NR/at least 6 m		Cesta, 2016 [10]	Cesta, 2016 [10]
amitriptyline	NR/at least 6 m		Cesta, 2016 [10]	Cesta, 2016 [10]
mianserin	NR/at least 6 m		Cesta, 2016 [10]	Cesta, 2016 [10]
mirtazapine	NR/at least 6 m		Cesta, 2016 [10]	Cesta, 2016 [10]
duloxetine	NR/at least 6 m		Cesta, 2016 [10]	Cesta, 2016 [10]
bupropion	NR/at least 6 m		Cesta, 2016 [10]	Cesta, 2016 [10]
agomelatine	NR/at least 6 m		Cesta, 2016 [10]	Cesta, 2016 [10]
anxiolytics	NR/NR		Goisis, 2023 [18]
diazepam	10–20 mg/NR		McIntosh, 2010 [33] Roest, 2019 [44]
clonazepam	0.5 mg 2x day/3 w		Rodrigues, 2014 [43]
Lorazepam	1 mg/NR		Roest, 2019 [44]
Midazolam	7.5 mg p.o.; 2–5 mg i.v.; 5 mg i.m./NR		Roest, 2019 [44]
Temazepam	10 mg/NR		Roest, 2019 [44]
Oxazepam	10–20 mg/NR		Roest, 2019 [44]

NR not reported; w week; d day; m month; p.o. per os; i.v. intravenous; i.m. intramuscular injection
^aadditionally cognitive-behavioral therapy was conducted
+ represents reporting in a single study

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