Fig. 4

Screening of genes associated with both cellular senescence and sphingolipid metabolism. A Venn diagram for intersection genes shared by WGCNA, DEGs and SMGs, and these genes were identified as DEGs-WGCNA-SMGs. B Venn diagram for intersection genes shared by WGCNA, DEGs and CSGs, and these genes were named DEGs-WGCNA-CSGs. C Dotplot for GO functional analysis and (D) dendrogram for KEGG pathway analysis of 79 DEGs associated with both cellular senescence and sphingolipid metabolism. E, F PPI network of these 79 DEGs. Threshold: adjusted P < 0.05. G Venn diagram for screening intersection genes based on four topological analysis algorithms—MCC, MNC, EPC, and Degree