Maternal obesity and the incidence of large-for-gestational-age newborns in isolated hypothyroxinemia pregnancies: a comparative cohort study

Table 4 Modification effect of BMI on associations between IMH and LGA neonates

	Euthyroid		IMH		Crude		P value ^a for Interaction	Adjusted ^b		P value ^a for Interaction
	Total	LGA (%)	Total	LGA (%)	OR (95% CI)	P value	P value ^a for Interaction	OR (95%CI)	P value	P value ^a for Interaction
Normal weight	2275	147 (6.5%)	27	5 (18.5%)	3.29 (1.23, 8.81)	0.018		2.86 (1.01, 8.12)	0.048
Overweight	5179	794 (15.3%)	305	38 (12.5%)	2.06 (1.41, 3.01)	< 0.001		2.00 (1.36, 2.96)	< 0.001
Obese	1859	512 (27.5%)	187	64 (34.2%)	7.53 (5.33, 10.64)	< 0.001	0.009	7.60 (5.26, 10.97)	< 0.001	0.013

^a Interaction test for BMI (normal weight vs. Overweight/obese) and IMH (euthyroid vs. IMH) on LGA risk. ^b Adjusted for adjusted for age, parity, BP, gestational age, assisted reproduction, pregnancy complications, neonatal sex, and laboratory findings (WBC, RBC, platelet, hemoglobin, hepatic and renal function, FT3, and TPO-Ab status). BMI, body mass index; IMH, isolated maternal hypothyroxinaemia; LGA, large for gestational age; CI, confidence interval; OR, odds ratio; RBC, red blood cell; WBC, white blood cell; FT3, free triiodothyronine; TPO-Ab, thyroid peroxidase antibody.

ISSN: 1477-7827