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Table 3 Association of BMI and IMH with fetal growth and SGA/LGA risk

From: Maternal obesity and the incidence of large-for-gestational-age newborns in isolated hypothyroxinemia pregnancies: a comparative cohort study

 

Birth length

Birth weight

SGA

LGA

β (95% CI)

P value

β (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

Model 1

 

Normal weight

0

 

0

 

1

 

1

 

Overweight

0.26 (0.20, 0.32)

< 0.001

212.91 (192.16, 233.67)

< 0.001

0.44 (0.38, 0.50)

< 0.001

2.74 (2.33, 3.22)

< 0.001

Obese

0.39 (0.31, 0.46)

< 0.001

360.26 (334.52, 386.00)

< 0.001

0.26 (0.21, 0.33)

< 0.001

5.80 (4.88, 6.89)

< 0.001

Per-1 kg/m2 increase

0.04 (0.03, 0.05)

< 0.001

39.45 (36.92, 41.98)

< 0.001

0.84 (0.82, 0.86)

< 0.001

1.18 (1.17, 1.20)

< 0.001

Euthyroid

0

 

0

 

1

 

1

 

IMH

0.01 (-0.11, 0.14)

0.839

43.54 (0.15, 86.93)

0.049

0.90 (0.65, 1.24)

0.516

1.41 (1.14, 1.76)

0.002

Model 2

        

Normal weight

0

 

0

 

1

 

1

 

Overweight

0.14 (0.09, 0.18)

< 0.001

167.01 (150.14, 183.88)

< 0.001

0.40 (0.35, 0.47)

< 0.001

2.67 (2.24, 3.17)

< 0.001

Obese

0.30 (0.24, 0.36)

< 0.001

323.96 (302.24, 345.68)

< 0.001

0.19 (0.15, 0.25)

< 0.001

5.88 (4.87, 7.11)

< 0.001

Per-1 kg/m2 increase

0.04 (0.03, 0.04)

< 0.001

37.79 (35.63, 39.95)

< 0.001

0.81 (0.79, 0.83)

< 0.001

1.20 (1.18, 1.22)

< 0.001

Euthyroid

0

 

0

 

1

 

1

 

IMH

0.10 (-0.00, 0.19)

0.052

53.29 (18.89, 87.69)

0.002

0.79 (0.56, 1.11)

0.169

1.32 (1.05, 1.65)

0.019

  1. Model 1 was unadjusted. Model 2 was adjusted for age, parity, BP, gestational age, assisted reproduction, pregnancy complications, neonatal sex, and laboratory findings (WBC, RBC, platelet, hemoglobin, hepatic and renal function, FT3, and TPO-Ab status). BMI, body mass index; IMH, isolated maternal hypothyroxinaemia; SGA/LGA, small/large for gestational age; CI, confidence interval; OR, odds ratio; RBC, red blood cell; WBC, white blood cell; FT3, free triiodothyronine; TPO-Ab, thyroid peroxidase antibody.