Maternal obesity and the incidence of large-for-gestational-age newborns in isolated hypothyroxinemia pregnancies: a comparative cohort study

Table 2 Association of BMI with thyroid hormone levels and IMH

	FT3 (pmol/L)		FT4 (pmol/L)		TSH (mIU/L)		IMH
	β (95% CI)	P value	β (95% CI)	P value	β (95% CI)	P value	OR (95% CI)	P value
Model 1
Normal weight	0		0		0		1
Overweight	0.11 (0.09, 0.14)	< 0.001	-0.89 (-0.97, -0.81)	< 0.001	-0.13 (-0.20, -0.05)	0.002	4.96 (3.34, 7.38)	< 0.001
Obese	0.25 (0.21, 0.28)	< 0.001	-1.37 (-1.47, -1.27)	< 0.001	-0.24 (-0.34, -0.14)	< 0.001	8.48 (5.64, 12.75)	< 0.001
Per-1 kg/m² increase	0.03 (0.02, 0.03)	< 0.001	-0.15 (-0.16, -0.14)	< 0.001	-0.03 (-0.04, -0.02)	< 0.001	1.16 (1.13, 1.18)	< 0.001
Model 2
Normal weight	0		0		0		1
Overweight	0.11 (0.08, 0.13)	< 0.001	-0.79 (-0.87, -0.71)	< 0.001	-0.11 (-0.19, -0.03)	0.005	4.63 (3.10, 6.91)	< 0.001
Obese	0.21 (0.18, 0.25)	< 0.001	-1.20 (-1.31, -1.10)	< 0.001	-0.24 (-0.34, -0.14)	< 0.001	6.96 (4.58, 10.58)	< 0.001
Per-1 kg/m² increase	0.02 (0.02, 0.03)	< 0.001	-0.13 (-0.14, -0.12)	< 0.001	-0.03 (-0.04, -0.02)	< 0.001	1.13 (1.10, 1.16)	< 0.001

Model 1 was unadjusted. Model 2 was adjusted for age, parity, BP, gestational age, assisted reproduction, pregnancy complications, and laboratory findings (WBC, RBC, platelet, hemoglobin, hepatic and renal function, and TPO-Ab status). BMI, body mass index; IMH, isolated maternal hypothyroxinaemia; FT3, free triiodothyronine; FT4, free thyroxine; TSH, thyroid stimulating hormone; CI, confidence interval; OR, odds ratio; RBC, red blood cell; WBC, white blood cell; TPO-Ab, thyroid peroxidase antibody.

ISSN: 1477-7827