Laparoscopically confirmed endometriosis and the risk of incident NAFLD: a prospective cohort study

Table 4 Association between endometriosis and incident NAFLD-accounting for delay between symptom onset and diagnosis

	Laparoscopically-confirmed endometriosis
	No	Yes
2-year delay between symptom onset and diagnosis
Cases	4,168	606
Person-years	1,210,535	102,533
Incidence rate ^†	3.44	5.91
Age-adjusted model	1.00	1.55 (1.42 − 1.68)
Multivariable model ^‡	1.00	1.22 (1.10 − 1.35)
4-year delay between symptom onset and diagnosis
Cases	4,159	615
Person-years	1,204,532	108,536
Incidence rate ^†	3.45	6.15
Age-adjusted model	1.00	1.55 (1.42 − 1.68)
Multivariable model ^‡	1.00	1.22 (1.10 − 1.36)

^† Per 1000 person-years
^‡ Model was adjusted for age, calendar year, race (White, non-White), BMI, smoking (never, past, current), alcohol intake (0, 0.1 − 4.9, 5 − 14.9, ≥ 15 g/day), physical activity (≤ 3, 3 − 8.9, 9 − 17.9, 18 − 26.9, ≥ 27 metabolic equivalent task-hours per week), AHEI, age at menarche (< 11, 12 − 13, ≥ 14 years old), history of infertility (yes, no), menstrual cycle irregularity (yes, no), use of oral contraceptive (never, past, current), hysterectomy/oophorectomy (yes, no), diabetes (yes, no), hypertension (yes, no), hypercholesterolemia (yes, no) and physical examination (yes, no)

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