Table 3 Subgroup analysis of diagnostic accuracy of TE biopsy/ SCM(WB/ICM)

TE biopsy

TE(WB/ICM)

16

0.839(0.790–0.879)

0.791(0.746–0.830)

0.878

20.300(12.700–30.800)

4.030(3.240–4.980)

0.205(0.151–0.270)

exclude mosaic

TE exclude mosaic (WB/ICM)

15

0.875(0.822–0.914)

0.864(0.802–0.909)

0.926

46.300(25.300–78.100)

6.560(4.420–9.550)

0.147(0.100-0.206)

PGT-A/SR

TE-PGT-A(WB/ICM)

13

0.821(0.758–0.871)

0.776(0.736–0.811)

0.806

16.300(10.000-25.200)

3.670(3.020–4.420)

0.233(0.165–0.315)

TE-PGT-SR(WB/ICM)

2

0.928(0.752–0.982)

0.882(0.690–0.962)

0.957

153.000(14.600–636.000)

9.170(2.900–24.000)

0.102(0.021–0.292)

WB/ICM

TE(WB)

9

0.880(0.816–0.924)

0.786(0.696–0.856)

0.907

28.000(16.400–44.900)

4.200(2.950–5.920)

0.156(0.101–0.226)

TE(ICM)

8

0.827(0.742–0.887)

0.793(0.726–0.848)

0.867

19.600(8.920–37.500)

4.050(2.860–5.590)

0.224(0.138–0.337)

prospective(A)

TE(WB/ICM)

12

0.820(0.756–0.871)

0.779(0.739–0.815)

0.807

16.600(10.100–25.800)

3.730(3.050–4.510)

0.233(0.164–0.317)

Age

PGT-A(age<38)

6

0.732(0.607–0.829)

0.766(0.699–0.822)

0.793

9.460(4.680–17.200)

3.150(2.310–4.190)

0.355(0.223–0.517)

PGT-A(age ≥ 38)

4

0.817(0.711–0.890)

0.756(0.606–0.862)

0.856

15.400(5.510–34.600)

3.490(2.030–5.940)

0.252(0.144–0.402)

Embryo quality

TE-C

6

0.835(0.759–0.891)

0.772(0.708–0.826)

0.848

18.100(9.130–32.300)

3.700(2.760–4.880)

0.218(0.139–0.322)

TE-A/B

8

0.778(0.681–0.852)

0.846(0.779–0.895)

0.885

20.600(9.310–39.700)

5.140(3.360–7.600)

0.267(0.172–0.386)

Index Test

N

Sensitivity % (95% CI)

Specificity % (95% CI)

AUC

DOR (97.5% CI)

Positive LR (97.5% CI)

Negative LR (97.5% CI)

SCM

SCM(WB/ICM)

9

0.874(0.825–0.911)

0.719(0.650–0.780)

0.869

18.400(10.800–29.300)

3.140(2.480–3.970)

0.178(0.123–0.247)

exclude mosaic

SCM exclude mosaic (WB/ICM)

9

0.888(0.827–0.929)

0.782(0.705–0.843)

0.910

29.500(16.100–49.800)

4.120(3.030–5.570)

0.147(0.092–0.219)

frozen

SCM-frozen (WB/ICM)

8

0.885(0.820–0.929)

0.716(0.630–0.790)

0.886

20.500(10.200–37.000)

3.160(2.370–4.200)

0.165(0.099–0.255)

PGT-A

SCM-PGT-A(WB/ICM)

7

0.870(0.807–0.915)

0.668(0.562–0.759)

0.871

14.100(7.280–24.800)

2.660(1.980–3.590)

0.200(0.128–0.295)

WB/ICM

SCM(WB)

8

0.863(0.805–0.906)

0.739(0.679–0.773)

0.876

17.400(10.400–27.400)

3.190(2.650–3.820)

0.191(0.129–0.270)

SCM(ICM)

3

0.918(0.809–0.967)

0.687(0.444–0.858)

0.914

32.500(5.710–106.000)

3.200(1.610–6.460)

0.137(0.045–0.318)

Embryo quality

TE-C

2

0.859(0.780–0.913)

0.674(0.540–0.784)

0.857

13.700(5.620–28.200)

2.700(1.830–4.010)

0.217(0.126–0.347)

TE-A/B

2

0.835(0.563–0.951)

0.484(0.085–0.905)

0.825

12.000(0.322–69.300)

2.350(0.796–8.610)

0.587(0.0835-2.460)