Table 1 Key clinical articles included in the review
From: The role of recombinant LH in ovarian stimulation: what’s new?
Study design | Patients involved | Intervention | Comparator | Results | |
|---|---|---|---|---|---|
Hypo-responders | |||||
Conforti et al. 2019 | Meta-analysis (4 RCTs + 1 prospective study) | Hypo-responders | r-hFSH and r-hLH co-treatment | r-hFSH monotherapy | Significantly higher clinical pregnancy rates, implantation rates, number of oocytes retrieved |
Advanced maternal age | |||||
Conforti et al. 2021 | Meta-analysis (12 RCTs) | Advanced maternal age (≥35 years) | r-hFSH and r-hLH co-treatment | r-hFSH monotherapy | Significantly higher clinical pregnancy rates, and implantation rates, in women between 35–40 years old |
Hypogonadotropic hypogonadal | |||||
Carone et al. 2012 [94] | RCT | Hypogonadotropic hypogonadal women | r-hFSH and r-hLH co-treatment | hMG | Significantly higher clinical pregnancy rate |
Huseyin et al. 2019 [99] | Retrospective study | Hypogonadotropic hypogonadal women | r-hFSH and r-hLH co-treatment | hMG | Significantly lower cancellation rate |
Progesterone rise | |||||
Werner et al. 2014 [87] | Retrospective study | 10,280 patients first IVF cycle | FSH plus LH formulations | FSH monotherapy | Stimulations using no administered LH had the highest risk of progesterone elevation ≥ 1.5 ng/mL |
Hugues et al. 2012 [91] | Systematic review (34 studies) | Women undergoing MAR techniques | hMG, r-hLH, or hCG | FSH monotherapy | Comparable risk of progesterone rise |
Implantation failure | |||||
Rahman et al. 2017 [92] | RCT | Women with 2 previous failed implantations | r-hFSH and r-hLH co-treatment | r-hFSH monotherapy | Significantly higher implantation rate and pregnancy rate; significantly lower abortion rate |
Poor response according to Bologna criteria | |||||
Humaidan et al. 2017 [42] | RCT | Women fulfilling Bologna criteria | r-hFSH and r-hLH co-treatment | r-hFSH monotherapy | Significantly higher cumulative live birth rate in women with moderate or severe BSC |
Lehert et al. 2021 [44] | Retrospective study | Women fulfilling Bologna criteria | r-hFSH and r-hLH co-treatment | r-hFSH monotherapy | Significantly higher cumulative live birth rate in women with moderate or severe BSC |