Fig. 4
The genomic landscape of human ovarian failure. Patients with ovarian failure presented single nucleotide variants (SNVs) in key genes (yellow) involved in DNA mismatch repair; homologous recombination; Fanconi anemia; the metaphase to anaphase transitions during meiosis; kinetochore-microtubule or centromere-kinetochore attachments and segregation during anaphase; chromatin organization; reduction of granulosa cell competency; perturbation of mitochondrial activities; pro-inflammatory responses; and necroptosis