Fig. 3

Quercetin enhances decidualization by control-eSCs and endometriosis-eSCs, as determined by IGFBP1 and PRL protein production. (A-H) Endometrial stromal cells (eSCs) from controls (A, C, E, and G, CTRL) and endometriosis cases (B, D, F, and H, ENDO) were treated with vehicle (Veh) or quercetin (Q, 25µM) for 4 h prior to the addition of cAMP alone (A-B, E-F) or cAMP + MPA (C-D, G-H). After 48 h, decidualization was analyzed by measuring IGFBP1 (A-D) or PRL (E-H) levels by ELISA. Data points connected by a line represent paired data points from one individual’s eSCs (± Q). *p < 0.05 Veh vs. Q-treated; **p < 0.01 Veh vs. Q-treated; ***P < 0.001 Veh vs. Q-treated; ****p < 0.0001 Veh vs. Q-treated