Fig. 10

The AKT and ERK1/2 signaling pathways promote cell survival and proliferation and suppress apoptosis. Quercetin (QUE) promotes apoptosis in eSCs by inhibiting the AKT and ERK1/2 pathways and enhancing p53 stability and apoptosis. Green and red solid lines indicate positive and negative effects, respectively, based on our data. Dashed red lines indicate proposed negative effects. Created with biorender.com