Fig. 8
Nur77 improves ovarian aging in reproductively aging mice through AKT/mTOR pathway. A PPI network was constructed by String, hub genes were identified, and predicted functional partners. B Molecular docking analysis. Nur77 was selected as the receptor protein, and AKT was selected as the ligand protein. Blue represents the hydrogen bond. Nur77 is green, and AKT is purple. C and D The protein expression levels of p-mTOR/mTOR and p-AKT/AKT in each group after overexpression of Nur77. Error bars, mean ± SEM. n = 6–8 per group. *P < 0.05, **P < 0.01