Fig. 3
From: DNA methylation landscape in pregnancy-induced hypertension: progress and challenges
The occurrence of PIH is associated with differential DNA methylation of placental genes. This figure illustrates the genes in the placenta that contribute to PIH due to variations in DNA methylation. These genes include imprinted genes, tumor suppressor genes, placental classical signaling pathways, placental microRNAs, and several other protein genes. Abbreviation: hyper, hypermethylation; hypo, hypomethylation; + , promote; -, inhibit; TFPI2, tissue factor pathway inhibitor 2; VHL, von Hippel Lindau tumor suppressor; RARRES1, retinoic acid receptor responder 1; TGF, transforming growth factor; DLL1, Delta-like 1; BCL-2, B-cell CLL/lymphoma 2; FABP4, fatty acid binding protein 4; ROS, reactive oxygen species; Bcl-xl, B-cell lymphoma-extra large; YAP1, Yes-associated protein 1; FOXO3, Forkhead-box O3; IGFBP5, insulin-like growth factor-binding protein 5; IGF, insulin-like growth factor; PAX3, Paired Box 3; YWHAQ, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; ERO1α, endoplasmic reticulum oxidase 1α; SERPINA3, serpin peptidase inhibitor clade A member 3; CMIP, C-Maf inducing protein; CTGF, connective tissue growth factor