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Table 3 Comparisons of cumulative clinical outcomes before and after propensity score matching

From: Does growth hormone supplementation of in vitro fertilization/intracytoplasmic sperm injection improve cumulative live birth rates in women with poor embryonic development in the previous cycle?

Characteristic

 

Before propensity score matching

 

After propensity score matching

Growth hormone (n = 1,326)

Control (n = 1,717)

aRR (95%CI)a

P value

Growth hormone (n = 694)

Control (n = 694)

aRR (95%CI)a

P value

Cumulative live birth

499 (37.6%)

390 (22.7%)

1.5 (1.2, 1.7)

 < 0.01

241 (34.7%)

191 (27.5%)

1.4 (1.1, 1.8)

 < 0.01

Live birth of first transfer

325 (24.51%)

277 (16.13%)

1.4 (1.2, 1.7)

 < 0.01

172 (24.8%)

130 (18.7%)

1.4 (1.1, 1.8)

 < 0.01

Biochemical pregnancy

624 (47.1%)

521 (30.3%)

1.5 (1.3, 1.8)

 < 0.01

306 (44.1%)

244 (35.2%)

1.5 (1.2, 1.8)

 < 0.01

Clinical pregnancy

578 (43.6%)

472 (27.5%)

1.50 (1.3, 1.8)

 < 0.01

281 (40.5%)

223 (32.1%)

1.4 (1.1, 1.8)

 < 0.01

Ongoing pregnancy

503 (37.9%)

393 (22.9%)

1.5 (1.3, 1.8)

 < 0.01

241 (34.7%)

192 (27.7%)

1.4 (1.1, 1.8)

 < 0.01

Twin pregnancy

99 (19.5%)

55 (13.6%)

1.5 (1.0, 2.1)

0.05

50 (20.5%)

31 (15.8%)

1.4 (0.8, 2.3)

0.21

Miscarriage

80 (6.0%)

85 (5.0%)

1.2 (0.9, 1.7)

0.20

40 (5.8%)

34 (4.9%)

1.2 (0.8, 2.0)

0.47

Ectopic pregnancy

5 (0.4%)

2 (0.1%)

3.4 (0.6, 19.0)

0.17

3 (0.4%)

1 (0.1%)

3.0 (0.3, 30.7)

0.62

Birth weight (kg)

 Singleton

  Mean

3.3 ± 0.6

3.3 ± 0.5

NA

0.20

3.3 ± 0.5

3.3 ± 0.5

NA

0.25

  Number of observations

408

351

  

173

132

  

  Low birth weight

2.0 ± 0.3

2.1 ± 0.4

NA

0.36

2.1 ± 0.3

2.2 ± 0.3

NA

0.64

  Macrosomic infants

4.2 ± 0.3

4.2 ± 0.2

NA

0.61

4.2 ± 0.3

4.2 ± 0.1

NA

0.60

 Twins

  Mean

2.5 ± 0.4

2.4 ± 0.4

NA

0.68

2.5 ± 0.4

2.5 ± 0.4

NA

0.89

  Number of observations

99

55

  

50

31

  

  Low birth weight

2.1 ± 0.4

2.1 ± 0.3

NA

0.92

2.1 ± 0.4

2.1 ± 0.3

NA

0.92

  Macrosomic infants

NA

NA

NA

NA

NA

NA

NA

NA

  Gestation delivery in weeks

38.3 ± 2.1

38.4 ± 2.1

NA

0.49

38.5 ± 1.9

38.3 ± 2.1

NA

0.29

Fetal sex

 Singleton

  

NA

0.81

  

NA

0.52

  Female

158 (48.0%)

124 (49.0%)

  

88 (50.9%)

72 (54.5%)

  

  Male

171 (52.0%)

129 (51.0%)

  

85 (49.1%)

60 (45.5%)

  

 Twins

  

NA

0.59

  

NA

0.89

  Female twins

29 (29.3%)

12 (21.8%)

  

12 (24.0%)

6 (19.4%)

  

  Male twins

26 (26.3%)

15 (27.3%)

  

15 (30.0%)

10 (32.3%)

  

  Boy-girl twins

44 (44.4%)

28 (50.9%)

  

23 (46.0%)

15 (48.4%)

  

  Preterm birth

91 (18.2%)

63 (16.2%)

1.19 (0.83, 1.72)

0.35

35 (14.5%)

34 (17.8%)

0.8 (0.5, 1.4)

0.36

 Type of delivery

  

NA

0.12

  

NA

0.29

  Vaginal

101 (20.2%)

96 (24.6%)

  

49 (20.3%)

47 (24.6%)

  

  Cesarean section

398 (79.8%)

294 (75.4%)

  

192 (79.7%)

144 (75.4%)

  
  1. aOR adjusted odds ratio, CI confidence interval, NA not available/applicable
  2. aAdjusted for female age, male age, basal FSH, AFC, BMI, infertility duration, and infertility type