Fig. 3

Functional enrichment analysis and canonical pathways predicted to be affected by Ingenuity Pathway Analysis (IPA). Functional implications of relevant significantly downregulated and upregulated genes in (A) ADENO-SECorg with respect to CONTROL-SECorg or (B) ADENO-GESTorg with respect to CONTROL-GESTorg. Differential expression of the genes is showed in a box under the gene in blue (downregulated) and red (upregulated) by means of log2FC scale. Downregulated and upregulated canonical pathways predicted by IPA and deemed relevant for adenomyosis pathogenesis and associated-infertility in (C) ADENO-SECorg and (D) ADENO-GESTorg. DEGs, differentially expressed genes