Table 2 Summary of results of treatment options with regard to implantation rate, clinical pregnancy rate, and live birth rate
Implantation Rate | Clinical Pregnancy Rate | Live Birth Outcome | Source | |
|---|---|---|---|---|
(treatment vs. control) | (treatment vs. control) | (treatment vs. control) | ||
Tacrolimus | 45.7% vs. 0% | 64% vs. 0% | 60% vs. 0% | Nakagawa et al., 2015 [36] |
(P < 0.0001) | (P < 0.0001) | (P < 0.0001) | ||
IVIG | 34.4% vs. 13.7% | 60.2% vs. 39.3% | 49.8% vs. 31.6% | Li et al., 2013 [82] (meta-analysis) |
RR 2.708 | RR 1.475 | RR 1.616 | ||
(95% CI: 1.302–5.629, I2 = 65.0%) | (95% CI: 1.191–1.825, I2 = 65.7%) | (95% CI: 1.243–2.101, I2 = 58.2%) | ||
PBMC | 22% vs. 4.88% | 39.58% vs. 14.29% | 33.33% vs.9.58% | Li et al., 2017 [84] |
(P = 0.014) | (P = 0.038) | (P = 0.038) | ||
G-CSF | 31.5% vs. 13.9% | 48.1% vs. 25% | 33.3% vs. 17.3% | Xu et al., 2015 [87] |
(P < 0.01) | (P < 0.01) | NS | ||
Antibiotics for CE | 37% vs. 17% | 65.2% vs. 33% | 60.8% vs. 13.3% | Cicinelli et al., 2015 [44] |
NS | (P = 0.039) | (P = 0.02) | ||
Salpingectomy | 25.6% vs. 12.3% | 45.7% vs. 22.5% | 40% vs. 17.5% | Strandell et al., 1999 [94] |
(P = 0.038) | (P = 0.029) | (P = 0.038) | ||
Endometrial Biopsy | 27.7%, vs. 14.2% | 66.7% vs. 30.3% | 48.9% vs. 22.5% | Barash et al., 2003 [96] |
(P = .00011) | (P = .00009) | (P = .016) | ||
IMSI procedure | 19.2% vs. 7.8% | 43.1% vs. 10.5% | 34.7% vs. 0% | Shalom-Paz et al., 2015 [109] |
(P = 0.042) | (P = 0.02) | (P = 0.003) |